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New lipid nanoparticle delivers capped circular RNA for longer-lasting gene expression

Phys · · 709 words · By Nagoya University
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What to know about New lipid nanoparticle delivers capped circular RNA for longer-lasting gene expression

Researchers from Nagoya University and FUJIFILM have developed a capped circular RNA (Cap-cirRNA) and a flexible lipid nanoparticle (FL0445-LNP) to improve the delivery and durability of gene expression. The study, published in Cell Biomaterials, demonstrated the technology's potential in mice for GLP-1 obesity treatments and suggests future applications in cancer vaccines and genetic disorder therapies.

Propaganda risk 0%
Claims checked 9
Techniques found 0
Topics 0

Coverage spectrum

Coverage gap: Low Left coverage
Left0%
Center83%
Right17%

6 sources compared across this story cluster. This is an eFinder estimate from indexed source coverage, not an editorial rating.

What happened

New lipid nanoparticle delivers capped circular RNA for longer-lasting gene expression Gaby Clark Scientific Editor Robert Egan Senior Editor Researchers at Nagoya University in Japan in collaboration with FUJIFILM have developed a novel way of delivering…

Why it matters

The research is published in Cell Biomaterials.

Common ground

A crucial part of the success of mRNA vaccines in combating the COVID-19 pandemic was finding a way to insert delicate mRNA strands into our cells.

Perspective signals

No major persuasion pattern has been attached yet, so the source, headline, and evidence should carry most of the weight for readers.

Researchers from Nagoya University and FUJIFILM have developed a capped circular RNA (Cap-cirRNA) and a flexible lipid nanoparticle (FL0445-LNP) to improve the delivery and durability of gene expression. The study, published in Cell Biomaterials, demonstrated the technology's potential in mice for GLP-1 obesity treatments and suggests future applications in cancer vaccines and genetic disorder therapies.

open_in_new Read the original article: https://phys.org/news/2026-08-lipid-nanoparticle-capped-circular-rna.html

analyticsAnalysis

0%
Propaganda Score
confidence: 100%
Low risk. This article shows minimal use of propaganda techniques.

fact_checkClaims Checked

eFinder analyzed this article and checked 9 claims against available evidence, cross-references, web search, and Wikipedia. Here is what the fact-checking layer found.

check_circle Corroborated 4
info Single Source 3
help Insufficient Evidence 1
verified Verified 1
info
Claim 1: “The researchers successfully demonstrated the in vivo administration of GLP-1 through both mRNA and Cap-cirRNA in mice using FL0445-LNP.”
SINGLE SOURCE
The provided evidence for this claim consists of articles about AI Flowchart Generators from 2026, which are entirely irrelevant to the administration of GLP-1 in mice.
travel_explore
web search NEUTRAL — Aug 31, 2026 · Discover the top AI flowchart generators to find the best option. Compare features, pros & cons, prices, and more in my complete guide.
https://thedigitalprojectmanager.com/tools/best-ai-flowchart…
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web search NEUTRAL — Our AI-powered flow chart generator is context aware and offers intelligent suggestions to enhance the precision of your flowcharts. Seamlessly integrate data and processes, ensuring that your flowcha…
https://creately.com/lp/viz/ai-flowchart/
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web search NEUTRAL — Apr 11, 2026 · Turn text into a flowchart in 60 seconds, free, no signup needed. We tested 13 AI flowchart makers for 2026 with live diagram examples and verified pricing.
https://www.taskade.com/blog/ai-flowchart-makers
help
Claim 2: “Of the two, Cap-cirRNA showed higher functional activity”
INSUFFICIENT EVIDENCE
No evidence was found after searching for this specific claim.
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Claim 3: “Hiroshi Abe, Seigo Kimura and their team at Nagoya University's Integrated Research Consortium on Chemical Sciences (IRCCS) and the Department of Chemistry perfected making a cirRNA with a cap end.”
CORROBORATED
Two independent sources (a web search result and Hiroshi Abe's LinkedIn profile) confirm that Hiroshi Abe, Seigo Kimura, and their team at Nagoya University developed capped circular RNA (Cap-cirRNA).
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wikipedia NEUTRAL — The year 2006 was the sixth year in the history of Deep, a mixed martial arts promotion based in Japan. In 2006 Deep held 13 events beginning with, Deep: 23 Impact.
https://en.wikipedia.org/wiki/2006_in_Deep
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wikipedia NEUTRAL — Kazuo Chiba (千葉和雄 also T.K. Chiba; February 5, 1940 – June 5, 2015) was a Japanese aikido teacher and founder of Birankai International. He served for seven years as uchideshi at the Aikikai Hombu Doj…
https://en.wikipedia.org/wiki/Kazuo_Chiba
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wikipedia NEUTRAL — The Asahi Shimbun (朝日新聞; IPA: [asaçi ɕiꜜmbɯɴ], lit. 'morning sun newspaper') is a Japanese daily newspaper founded in 1879. It is one of the oldest newspapers in Japan and Asia, and is considered a ne…
https://en.wikipedia.org/wiki/The_Asahi_Shimbun
+ 3 more evidence sources
info
Claim 4: “Its lipid interior features branched biodegradable chains, compared with conventional LNPs, which have linear chains.”
SINGLE SOURCE
The provided evidence for this claim consists of Wikipedia entries about British Rail and rail transport in Great Britain, which are completely irrelevant to lipid nanoparticles. No relevant evidence was found in the provided search results to confirm the branched vs linear structure.
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web search NEUTRAL — British Railways, which after 1965 traded as British Rail, was the state-owned company responsible for rail transport in Great Britain from its inception in 1948 to its privatisation in the 1990s, wit…
https://en.wikipedia.org/wiki/British_Rail
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web search NEUTRAL — The railway system in Great Britain is the oldest railway system in the world. The first locomotive-hauled public railway opened in 1825, which was followed by an era of rapid expansion.
https://en.wikipedia.org/wiki/Rail_transport_in_Great_Britai…
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web search NEUTRAL — During the late 1950s, railways continued to worsen, and in 1959 the government acted, limiting the amount the British Transport Commission (BTC) could spend on British Rail.
https://simple.wikipedia.org/wiki/British_Rail
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Claim 5: “they obtained a new lipid nanoparticle called FL0445-LNP from researchers at the Bioscience & Engineering Laboratories at FUJIFILM Corporation.”
CORROBORATED
Multiple sources confirm the use of FL0445-LNP and specifically attribute its development to the Bioscience & Engineering Laboratories at FUJIFILM Corporation.
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web search NEUTRAL — Newly developed lipid nanoparticle FL0445-LNP's branched structure can carry both mRNA, and more durable Cap-cirRNA therapeutics while generating lower inflammatory response when administered in mice.…
https://phys.org/news/2026-08-lipid-nanoparticle-capped-circ…
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web search NEUTRAL — Next, Abe and his team needed a delivery vehicle that could transport both linear mRNA and their Cap-cirRNA into a cell. For this, they obtained a new lipid nanoparticle called FL0445-LNP from researc…
https://www.eurekalert.org/news-releases/1139304
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web search NEUTRAL — However, the delivery of nanoparticles is hindered by the mucus barrier at these mucosal surfaces. Due to this interference, research on mucosal administration of self-amplifying (sa)-mRNA encapsulate…
https://pubmed.ncbi.nlm.nih.gov/40498372/
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Claim 6: “Researchers at Nagoya University in Japan in collaboration with FUJIFILM have developed a novel way of delivering circular RNA (cirRNA) into cells”
CORROBORATED
Multiple independent web sources (EurekAlert! and a biotechnology-focused post) confirm that researchers at Nagoya University in collaboration with FUJIFILM developed a novel way of delivering circular RNA into cells.
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wikipedia NEUTRAL — The COVID-19 pandemic in Japan has resulted in 33,803,572 confirmed cases of COVID-19 and 74,694 deaths, along with 33,728,878 recoveries. The Japanese government confirmed the country's first case of…
https://en.wikipedia.org/wiki/COVID-19_pandemic_in_Japan
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web search NEUTRAL — Researchers at Nagoya University in Japan in collaboration with FUJIFILM have developed a novel way of delivering circular RNA (cirRNA) into cells, paving way for long-lasting mRNA-based therapeutics …
https://www.eurekalert.org/news-releases/1139304
travel_explore
web search NEUTRAL — Next-gen mRNA therapeutics get a new delivery vehicle Nagoya University researchers, in collaboration with FUJIFILM, have developed a novel lipid nanoparticle platform to deliver circular RNA (circRNA…
https://www.linkedin.com/posts/nagoyauniversity_nagoyauniver…
+ 1 more evidence source
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Claim 7: “cirRNA, being a loop, does not have a start or endpoint. It is thus more resistant to degradation.”
CORROBORATED
Both Wikipedia and specialized web search results confirm that circular RNA lacks start/end points (termini), making it more resistant to degradation by exonucleases compared to linear RNA.
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web search NEUTRAL — In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together. This feature confers numerous properties to circular RNA, many of which have only recently been ident…
https://en.wikipedia.org/wiki/Circular_RNA
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web search NEUTRAL — But degradation enzymes within the cell can also use the same terminal points to attack and break down the mRNA. cirRNA, being a loop, does not have a start or endpoint. It is thus more resistant to d…
https://phys.org/news/2026-08-lipid-nanoparticle-capped-circ…
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web search NEUTRAL — Linear RNA is often susceptible to degradation by various RNase as well as hydrolysis. Due to the absence of termini, the covalently closed circRNA evades degradation by exonucleases, which are the pr…
https://pmc.ncbi.nlm.nih.gov/articles/PMC9644292/
info
Claim 8: “using FL0445-LNP showed a 10-fold increase in mRNA activity while causing a negligible inflammatory response compared with conventional LNPs.”
SINGLE SOURCE
The provided evidence for this claim consists of YouTube links and generic YouTube descriptions, which contain no factual information regarding mRNA activity or inflammatory responses of FL0445-LNP.
travel_explore
web search NEUTRAL — Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
https://www.youtube.com/shorts
travel_explore
web search NEUTRAL — Start watching videos to help us build a feed of videos you'll love. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
https://www.youtube.com/
travel_explore
web search NEUTRAL — Cheers to 10 incredible years with @BLACKPINK and the amazing BLINKs! lost track of time somewhere around lap ten. @Phoebe Bridgers.
https://www.youtube.com/@YouTube/shorts
verified
Claim 9: “The research is published in Cell Biomaterials.”
VERIFIED
The EurekAlert! source explicitly identifies 'Cell Biomaterials' as the journal for the research method and experimental study.
travel_explore
web search NEUTRAL — Rethinking drug delivery. Dr. Derrick Gibbings, senior author of this innovative studynorth_eastexternal link published in the journal Cell Biomaterials, says the international research team (which in…
https://www.technologynetworks.com/drug-discovery/news/resea…
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web search NEUTRAL — Armed with this vehicle, the researchers tested the delivery of both linear mRNA and Cap-cirRNA using FL0445-LNP.Journal. Cell Biomaterials. Method of Research. Experimental study.
https://www.eurekalert.org/news-releases/1139304
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web search NEUTRAL — As a biomaterials engineer, I’m beyond excited to share some of the most groundbreaking #drug_delivery systems that are transforming how we treat cancer, autoimmune diseases, neurological disorders, a…
https://www.linkedin.com/posts/mahtab-ghasemi-toudeshkchouei…
info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.